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Description
Human YWHAH/14-3-3 eta Protein, His TagProduct Specification Species Human Synonyms 14 3 3 protein eta, Protein AS1, YWHA1 Accession Q04917 Amino Acid Sequence Protein sequence (Q04917, Met1 Asn246, with C His Tag) MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN Expression System E. coli
Product Specification
| Species | Human |
| Synonyms | 14-3-3 protein eta, Protein AS1, YWHA1 |
| Accession | Q04917 |
| Amino Acid Sequence | Protein sequence (Q04917, Met1-Asn246, with C-His Tag) MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 29.9 kDa Observed MW: 30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
14-3-3 protein eta (YWHAH) is a prominent isoform within the conserved 14-3-3 family. It regulates diverse cellular processes by binding to phosphorylated serine/threonine motifs on client proteins. This interaction allows it to modulate target protein localization, stability, and activity. 14-3-3 eta is critically involved in signal transduction, cell cycle control, and apoptosis. Notably, it plays a specialized role in neuronal function and survival. Its dysregulation is linked to major pathological conditions, including cancer and neurodegenerative diseases like Parkinson's. Furthermore, 14-3-3 eta has emerged as a valuable biomarker in rheumatoid arthritis, where its detection in serum aids diagnosis.
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