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Description
Human ADAM22 Protein, His TagProduct Specification Species Human Synonyms Disintegrin and metalloproteinase domain containing protein 22, Metalloproteinase disintegrin ADAM22 3, Metalloproteinase like, disintegrin like, and cysteine rich protein 2, MDC2 Accession Q9P0K1 Amino Acid Sequence Protein sequence (Q9P0K1, Gly26 His528(Leu78Val), with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Disintegrin and metalloproteinase domain-containing protein 22, Metalloproteinase-disintegrin ADAM22-3, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2, MDC2 |
| Accession | Q9P0K1 |
| Amino Acid Sequence | Protein sequence (Q9P0K1, Gly26-His528(Leu78Val), with C-His Tag) GQAGDASLMELEKRKENRFVERQSIVPLRLIYRSGGEDESRHDALDTRVRGDVGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIH |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 58.2 kDa Observed MW: 40 kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease) family of transmembrane proteins. Unlike many family members, it lacks proteolytic activity and functions primarily as a scaffold protein within the central nervous system. Its key role is to anchor the protein complex at the synapse that includes postsynaptic receptors and signaling molecules. By interacting with specific partners like LGI1 and PSD-95, ADAM22 is crucial for organizing the synaptic architecture at excitatory synapses, thereby facilitating proper neuronal communication. Mutations in genes encoding ADAM22 or its binding partners are linked to severe epileptic disorders.
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