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Description
IL1RAP Recombinant Rabbit mAb (S-2655-56)Product Specification Host Rabbit Antigen IL1RAP Synonyms Interleukin 1 receptor accessory protein; IL 1 receptor accessory protein; IL 1RAcP; Interleukin 1 receptor 3 (IL 1R 3; IL 1R3); C3orf13; IL1R3 Immunogen Recombinant Protein Location Secreted, Cell membrane Accession Q9NPH3 Clone Number S 2655 56 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample A673 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | IL1RAP |
| Synonyms | Interleukin-1 receptor accessory protein; IL-1 receptor accessory protein; IL-1RAcP; Interleukin-1 receptor 3 (IL-1R-3; IL-1R3); C3orf13; IL1R3 |
| Immunogen | Recombinant Protein |
| Location | Secreted, Cell membrane |
| Accession | Q9NPH3 |
| Clone Number | S-2655-56 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | A673 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
IL1RAP (interleukin-1 receptor accessory protein) is a transmembrane glycoprotein that serves as the indispensable co-receptor for all members of the IL-1 cytokine family (IL-1α, IL-1β, IL-33, IL-36) by forming a trimeric ligand–primary receptor–IL1RAP complex whose intracellular TIR domains recruit MyD88, triggering sequential activation of IRAK4/IRAK1/2, TRAF6 and downstream MAPK (p38, JNK, ERK) and NF-κB pathways that drive inflammation, cell survival and proliferation; physiologically expressed at low levels in most normal tissues, IL1RAP is markedly up-regulated on the surface of hematologic and solid tumor cells where it additionally interacts with and amplifies oncogenic receptor tyrosine kinases such as FLT3 and c-Kit, and its high expression correlates with poor prognosis, making it a promising selective target for antibody, CAR-T and small-molecule therapies.
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