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Description
RBPMS Recombinant Rabbit mAb (S-2387-235)Product Specification Host Rabbit Antigen RBPMS Synonyms RNA binding protein with multiple splicing; RBP MS; Heart and RRM expressed sequence (Hermes); HERMES Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q93062 Clone Number S 2387 235 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt, Mk Positive Sample HepG2, A549, A431, HeLa, mouse heart, rat heart, COS 7 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | RBPMS |
| Synonyms | RNA-binding protein with multiple splicing; RBP-MS; Heart and RRM expressed sequence (Hermes); HERMES |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q93062 |
| Clone Number | S-2387-235 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HepG2, A549, A431, HeLa, mouse heart, rat heart, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| IF | 1:500 | Ms |
Background
RBPMS (RNA-binding protein with multiple splicing) is an RNA-recognition-motif protein that binds tandem CAC motifs in pre-mRNAs to orchestrate tissue-specific alternative splicing, mRNA stability and translational control; in the heart it regulates inclusion of sarcomeric exons (e.g., Ttn exon 47, Pdlim5, Nexn) essential for post-natal contractility, so its loss causes dilated cardiomyopathy and heart failure, while in retina and neurons it serves as a selective marker of retinal ganglion cells and modulates axonal integrity, and during development it governs cardiomyocyte cytokinesis, preventing premature binucleation and non-compaction cardiomyopathy, thereby exerting stage- and cell-type-specific control over RNA processing critical for vision, neural function and cardiac performance.
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