SKU: 89389694176

4-1BB/TNFRSF9 His Tag Protein, Mouse

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Description

4-1BB/TNFRSF9 His Tag Protein, MouseProduct Specification Species Mouse Synonyms TNFRSF9; 4 1BB; CD137; CDw137; ILA Accession P20334 Amino Acid Sequence Val24 Leu187, with C terminal His Expression System HEK293 Molecular Weight 25 33kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Mouse
Synonyms TNFRSF9; 4-1BB; CD137; CDw137; ILA
Accession P20334
Amino Acid Sequence Val24-Leu187, with C-terminal His
Expression System HEK293
Molecular Weight

25-33kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90. Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.

Background

CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.

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SKU: 89389694176

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4.2 ★★★★★
Based on 28 reviews
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Lonni W
Pawtucket, US
★★★★★ 3
below average value but decent quality on this 95.4% Polyester, 4.6% Spandex dress shirt
Special Size: Black Buttons, Size: Large, Color: Sky Blue, Special Size: Black Buttons, Size: Large, Color: Sky Blue
At $20 when I picked this up, it was overpriced for what it was. I'm held accountable to the value assigned to me at the time I select to review it, so I review the value based on what was assigned not on what it later becomes if they discount it. As I write this I can see it is in a value range it should have been for me, but I'm still reviewing it at the $20. That's overpriced on a 95.4% Polyester, 4.6% Spandex shirt (i.e., non-cotton) and so the value here is a 1/5 or 2/5, say 1.5/5 for it. In terms of quality, this is a poly dress shirt. Still, I'd call this a 4/5 for what it is. The standard is cotton, and in my experience, as someone in ties and collared shirts all day, I would note that I do prefer a 95 cotton/5 spandex blend, with the challenge that its not the most wrinkle free material. This blend, 95 poly/5 spandex, is a very wrinkle free and smooth feeling material. Poly has better durability than cotton despite feeling thinner, because it won't fray as much. That said, even though it's lightweight, poly will make you hotter because it doesn't breathe like cotton. It feels light, so you think it is going to be cooler, but in practice actually isn't really if it's a hot day. It can make you sweat more. That said, many people like poly blends for the ease of maintenance. I've given up dry cleaning, just too much, and I do like to avoid an iron, so I tested this out because of it. For me this fit well. I ordered a large (typically I prefer to wear a 16.5/34/35, and I'm 5'11, 185) and this fit well. It's not a slim fit (tapered bottom) for those who might complain about extra material. But it fit well. I put it through both the wash and dryer. It did not shrink (poly usually doesn't) to be out of size, but was fine, and of course came out without wrinkles. The collars have no stays, these poly shirts hardly ever do, but I have found they mostly remain flat, since the material doesn't tend to wrinkle, and thus my points stay in place just fine. At a 1.5 on value and a 4 on quality, this is a 2.75/5 average for me. Again, value plays a big part for me. So, full disclosure a better value would have raised my rating on this. But hopefully, based on what I covered above, you have enough to figure out if this shirt is worth it to you or not.
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Reviewed in the United States on March 2, 2026
G
Verified Purchase
Getahun Wuneh
Omaha, US
★★★★★ 5
Thev quality and size
Special Size: Black Buttons, Size: Large, Color: Grey
It's good fit
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 21, 2026
A
Amazon Customer
San Leandro, US
★★★★★ 5
Nice dress shirt
Special Size: Black Buttons, Size: Large, Color: Grey
This shirt is a super soft and an awesome style, which I really love. The material is a soft cotton and that doesn’t irritate my skin. It is breathable, but also keeps you relatively warm. It’s very nice looking on and would be okay for everyday wear. It has been used many times going out with jeans or shorts out. I wash and dry it regularly in a machine and still looks just as new as the out of box condition. There is no pilling, fabric change, or shrinking. The style is flattering, cut well, and runs true to size. Other shirts owned feel similar to this one, which meets expectations and is a nice shirt for the price. I do wish it had a pocket though. Ultimately would purchase again.
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Reviewed in the United States on April 7, 2026
A
A.T.
Louisville, US
★★★★★ 5
Sharp-looking business shirt at a great price
Special Size: Black Buttons, Size: X-Large, Color: Rhine Blue
This long sleeve dark blue shirt is a great choice for a business casual look. The "Rhine Blue" color really stands out — it’s very bold without being over the top, and it gives the shirt a sharp, polished appearance. The stitching is very well done, with clean lines and no loose threads, which adds to the overall quality. It fits nicely and maintains a crisp look throughout the day. The material is mostly polyester with some spandex, so it feels smooth, lightweight, and is actually breathable. It stays comfortable during long wear and doesn’t feel heavy or restrictive. Overall, it’s a sharp, well-made shirt that delivers both style and comfort at a great level. It was a good deal at the original price of about $20, but at the new price of about $15, it's an excellent deal. I may get another in a different color.
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Reviewed in the United States on March 29, 2026
V
Verified Purchase
Valerie Jones
Belleville, US
★★★★★ 5
Very comfortable and looks great!
Size: X-Large, Color: Navy Blue, Size: X-Large, Color: Navy Blue
This shirt is surprisingly really nice for the price. Really nice even regardless of the price. It fits and looks great on my hubby. We liked it so much that I bought him another one in a different color. Will probably even buy more. The large ran a little small, so we got him an extra large and it was great.
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Reviewed in the United States on February 6, 2026

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