SKU: 86468031419

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)

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Description

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)Product Specification Host Rabbit Antigen HDAC1 Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1 Immunogen Synthetic Peptide Location Nucleus Accession Q13547 Clone Number SDT 310 72 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, K562, NIH 3T3, C6 Predicted Reactivity Bv Purification Protein A Concentration 1 mg ml Conjugation HRP Physical Appearance Liquid Storage Buffer PBS,

Product Specification


Host Rabbit
Antigen HDAC1
Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1
Immunogen Synthetic Peptide
Location Nucleus
Accession Q13547
Clone Number SDT-310-72
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample HeLa, Jurkat, K562, NIH/3T3, C6
Predicted Reactivity Bv
Purification Protein A
Concentration 1 mg/ml
Conjugation HRP
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied.

Dilution


application dilution species
WB 1:10000 Hu, Ms, Rt

Background

Histone deacetylase 1 (HDAC1) is a key enzyme involved in the regulation of gene expression through the deacetylation of histone and non-histone proteins. As a zinc-dependent deacetylase, HDAC1 removes acetyl groups from lysine residues on histones, thereby tightening chromatin structure and inhibiting gene transcription. It is a component of several multiprotein complexes, such as the NuRD complex, which are involved in chromatin remodeling and transcriptional repression. HDAC1 plays a crucial role in various cellular processes, including cell cycle progression, differentiation, and development. In cancer, HDAC1 is often overexpressed and contributes to tumor progression by promoting cell proliferation and survival. For example, in colorectal cancer, HDAC1 enhances cell survival and proliferation in an ATG16L-dependent manner. Additionally, HDAC1 overexpression in cancer cells can be regulated by transcription factors like Sp1 and Sp3, which bind to the HDAC1 promoter and recruit other epigenetic modulators. In neurodegenerative diseases such as Alzheimer's disease, HDAC1 has been implicated in the regulation of oxidative DNA damage repair and synaptic function. Studies have shown that HDAC1 activity may be involved in the pathogenesis of Alzheimer's disease through its effects on DNA repair mechanisms and gene expression. HDAC1 is also a potential therapeutic target for neurological disorders, as HDAC inhibitors have shown promise in preclinical studies for treating conditions like Huntington's disease and Parkinson's disease.

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SKU: 86468031419

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Rachael
Chelsea, US
★★★★★ 5
My go to brand
My go to brand. Other brands I have to reapply constantly and still have sunburn. I love this brand and the stick is even better for applying sunscreen. Very reliable without any mess!
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Reviewed in the United States on February 3, 2025
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Nicole Ward
Louisville, US
★★★★★ 1
Not fur Surfing or other Water Sports
I got this in a swag bag from a surfing contest. The stick is very dry...that's the only way I can explain how it feels. It certainly doesn't glide on like other face sticks. After one wave and ducking my face in the water, the product smeared off and ran into my eyes. My vision got blurry from that, and it was really hard to see the waves coming in. I won't be using this product ever again. I also looked at the EWG website, and this product was given a 6. For those new to EWG, that's not a good rating. You want like a 1 or 2.
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Reviewed in the United States on January 10, 2026
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MJWalsh
West Palm Beach, US
★★★★★ 5
Perfect for travel
Nice size and easy to apply. And no burns!
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Reviewed in the United States on September 15, 2024
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J. Oks
San Leandro, US
★★★★★ 3
Too little product for the price
I was surprised at how little product you get for the price. After only two weeks, the bar already broke in half, and there's not much left. Additionally, it leaves white streaks, so you'll need to rub it in after applying. I still like the fact that it's got clean organic ingredients. I won't by the bar again, but I will try the spray
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Reviewed in the United States on June 3, 2024
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Savannah
Massapequa, US
★★★★★ 5
My favorite!
Best face sunscreen I've ever tried and I've tried a ton. I have very sensitive skin and I've left this sunscreen on overnight and it has not caused any issues no breakouts. I wish it had no fragrance but it doesn't smell the worst and my skin doesn't seem to mind. My husband refuses to wear traditional sunscreen but he loves this one because of how light it feels on your face.
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Reviewed in the United States on November 5, 2023

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