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Description
Mouse Anti-Human CD61 Antibody (S-R618)Product Specification Host Mouse Antigen CD61 Synonyms Integrin beta 3; Platelet membrane glycoprotein IIIa (GPIIIa); ITGB3; GP3A Location Cell membrane Accession P05106 Clone Number S R618 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of
Product Specification
| Host | Mouse |
| Antigen | CD61 |
| Synonyms | Integrin beta-3; Platelet membrane glycoprotein IIIa (GPIIIa); ITGB3; GP3A |
| Location | Cell membrane |
| Accession | P05106 |
| Clone Number | S-R618 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD61, also known as integrin β3 or GPIIIa, is a membrane glycoprotein that forms heterodimeric complexes with other integrins, such as CD41 (forming the GPIIb/IIIa complex) and CD51 (forming the αvβ3 integrin). It is primarily expressed on platelets, megakaryocytes, endothelial cells, osteoclasts, and some tumor cells. The CD61/CD41 complex is crucial for platelet aggregation and blood clotting through interactions with fibrinogen and von Willebrand factor. Additionally, CD61 plays a role in cell adhesion, migration, and invasion in various physiological and pathological processes, including tumor metastasis and viral infections. In clinical settings, CD61 is used as a biomarker for identifying platelets and megakaryocytes, and its upregulation in tumors is associated with poor prognosis in several cancers.
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