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Description
TERT Recombinant Rabbit mAb (S-1246-143)Product Specification Host Rabbit Antigen TERT Synonyms Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase associated protein 2 (TP2); EST2; TCS1; TRT Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession O14746 Clone Number S 1246 143 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM Reactivity Hu Positive Sample HeLa, Jurkat, K562 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | TERT |
| Synonyms | Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2 (TP2); EST2; TCS1; TRT |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | O14746 |
| Clone Number | S-1246-143 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu |
| Positive Sample | HeLa, Jurkat, K562 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | ICC |
| ICFCM | 1:500 | Hu |
Background
TERT, or telomerase reverse transcriptase, is a crucial component of the enzyme telomerase, which is responsible for maintaining the length of telomeres, the protective caps at the ends of chromosomes. TERT is composed of multiple domains, including a telomerase conserved motif domain, a catalytic domain, and an RNA-binding domain. It functions by reverse transcribing its RNA template into DNA and adding it to the telomere DNA sequence, ensuring the integrity of chromosomes during cell division. TERT expression is tightly regulated in normal cells but is often upregulated in cancer cells, contributing to their uncontrolled proliferation. Besides its role in telomere maintenance, TERT is also involved in DNA repair, cell survival, and proliferation, and it has been implicated in various diseases, including cancer and pulmonary fibrosis.
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