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Description
NMDAR2B Recombinant Rabbit mAb (S-1864-37)Product Specification Host Rabbit Antigen NMDAR2B Synonyms Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon 2; N methyl D aspartate receptor subtype 2B (NMDAR2B; NR2B); N methyl D aspartate receptor subunit 3 (NR3; hNR3); GRIN2B Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Lysosome, Endosome, Cell membrane Accession Q13224 Clone Number S 1864 37 Antibody Type Recombinant mAb Isotype IgG
Product Specification
| Host | Rabbit |
| Antigen | NMDAR2B |
| Synonyms | Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B (NMDAR2B; NR2B); N-methyl-D-aspartate receptor subunit 3 (NR3; hNR3); GRIN2B |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Lysosome, Endosome, Cell membrane |
| Accession | Q13224 |
| Clone Number | S-1864-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | Mouse brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
NMDAR2B protein, also known as GRIN2B or GluN2B, is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a ligand-gated ion channel that plays a crucial role in synaptic plasticity, learning, and memory formation. It is highly expressed in the brain and is involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency underlying certain types of memory. NMDAR2B is essential for brain development and synaptic function, with its phosphorylation at specific sites regulating receptor activity and localization. Additionally, NMDAR2B has been implicated in various neurological disorders, such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Recent studies also suggest its involvement in cancer progression, where it can be phosphorylated and interact with other proteins to enhance cell migration and invasion.
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