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Description
CBS Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen CBS Synonyms Cystathionine beta synthase; Beta thionase; Serine sulfhydrase Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P35520 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, IF Reactivity Ms, Rt Positive Sample mouse kidney, mouse liver, rat kidney, rat liver Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | CBS |
| Synonyms | Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P35520 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Ms, Rt |
| Positive Sample | mouse kidney, mouse liver, rat kidney, rat liver |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:250 | Ms, Rt |
| IF | 1:100-1:500 | Ms, Rt |
Background
Cystathionine beta-synthase (CBS) is a crucial enzyme in the trans-sulfuration pathway that catalyzes the conversion of homocysteine to cystathionine, which is subsequently converted to cysteine. It is a pyridoxal 5′-phosphate (PLP)-dependent enzyme with a modular three-domain structure. The N-terminal domain binds a heme cofactor that acts as a redox sensor, while the C-terminal domain contains a tandem CBS domain that binds S-adenosylmethionine (SAM), an allosteric activator. Mutations in the CBS gene can lead to homocystinuria, a condition associated with cardiovascular, ocular, skeletal, and central nervous system complications. CBS is also involved in hydrogen sulfide (H₂S) production, an important gasotransmitter with various physiological functions.
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