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Description
DLST Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen DLST Synonyms Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex, mitochondrial; 2 oxoglutarate dehydrogenase complex component E2 (OGDC E2); Dihydrolipoamide succinyltransferase component of 2 oxoglutarate dehydrogenase complex; E2K; DLTS Immunogen Synthetic Peptide Location Nucleus, Mitochondrion Accession P36957 Antibody Type Polyclonal antibody Isotype IgG
Product Specification
| Host | Rabbit |
| Antigen | DLST |
| Synonyms | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2 (OGDC-E2); Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; DLTS |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Mitochondrion |
| Accession | P36957 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HepG2, MCF7, 293T, NIH/3T3, mouse brain, C6, rat brain |
| Predicted Reactivity | Bv, Pg |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200-1:500 | Hu |
| ICC | 1:500 | Hu |
Background
DLST (dihydrolipoamide S-succinyltransferase) is a protein-coding gene located on chromosome 14 that encodes a mitochondrial protein belonging to the 2-oxoacid dehydrogenase family. This protein is the E2 component of the 2-oxoglutarate dehydrogenase complex, which catalyzes the conversion of 2-oxoglutarate to succinyl-CoA and CO₂, playing a crucial role in the citric acid cycle. DLST is expressed in various tissues, including the kidney and heart. Mutations in the DLST gene have been associated with diseases such as pheochromocytoma/paraganglioma syndrome.
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