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Description
Tau-441/2N4R His Tag Protein, HumanProduct Specification Species Human Synonyms Tau F,Tau 4,2N4R,Microtubule associated protein tau,Neurofibrillary tangle protein,Paired helical filament tau (PHF tau),MAPT,MAPTL,MTBT1,TAU Accession P10636 8 Amino Acid Sequence Met1 Try441, with C His tag Expression System CHO Molecular Weight Predicted MW: 47. 5 kDa Observed MW: 75 90 kDa Purity 90% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized
Product Specification
| Species | Human |
| Synonyms | Tau-F,Tau-4,2N4R,Microtubule-associated protein tau,Neurofibrillary tangle protein,Paired helical filament-tau (PHF-tau),MAPT,MAPTL,MTBT1,TAU |
| Accession | P10636-8 |
| Amino Acid Sequence |
Met1-Try441, with C-His tag
|
| Expression System | CHO |
| Molecular Weight |
Predicted MW: 47.5 kDa Observed MW: 75-90 kDa
|
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer |
0.2M PBS, pH7.4.
|
| Reconstitution |
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
|
| Stability & Storage |
12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The tau proteins (abbreviated from tubulin associated unit) form a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). They have roles primarily in maintaining the stability of microtubules in axons and are abundant in the neurons of the central nervous system (CNS), where the cerebral cortex has the highest abundance. They are less common elsewhere but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become hyperphosphorylated insoluble aggregates called neurofibrillary tangles.
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