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Description
Phospho-Serine/Threonine Recombinant Mouse mAb (S-3496)Product Specification Host Mouse Antigen Phospho Serine Threonine Clone Number S 3496 Antibody Type Mouse mAb Isotype IgG2b,k Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species WB 1: 1000 Hu
Product Specification
| Host | Mouse |
| Antigen | Phospho-Serine/Threonine |
| Clone Number | S-3496 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Phospho-serine and phospho-threonine are crucial post-translational modifications where a phosphate group is covalently attached to the hydroxyl side chain of specific serine or threonine residues within a protein. This phosphorylation event, primarily catalyzed by enzymes known as kinases, dramatically alters the protein's properties by introducing a bulky, negatively charged group. Consequently, it can induce conformational changes, create new binding sites for partner proteins, and fundamentally regulate the protein's activity, stability, localization, and interactions with other biomolecules. As one of the most ubiquitous and essential regulatory mechanisms in biology, serine/threonine phosphorylation is a central control point in countless cellular processes, including signal transduction, cell cycle progression, gene expression, and apoptosis. The dynamic nature of this modification, which can be reversed by phosphatases, allows cells to rapidly and reversibly respond to both internal and external stimuli.
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