Pay in installments of $37.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 25 - Jul 30
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Pacific Blue Mouse Anti-Human CD154 Antibody (S-R579)Product Specification Host Mouse Antigen CD154 Synonyms CD40 ligand; CD40 L; T cell antigen Gp39; TNF related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40L; TNFSF5; TRAP; CD40LG Location Cell membrane Accession P29965 Clone Number S R579 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample PMA and Ionomycin treated human PBMC Purification Protein G Concentration 0. 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD154 |
| Synonyms | CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40L; TNFSF5; TRAP; CD40LG |
| Location | Cell membrane |
| Accession | P29965 |
| Clone Number | S-R579 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | PMA and Ionomycin treated human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD154, also known as CD40 ligand (CD40L) or gp39, is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on activated CD4+ T cells and can also be found on other immune cells such as CD8+ T cells, natural killer cells, platelets, dendritic cells, and endothelial cells. CD154 can form a trimeric structure and is crucial for humoral and cellular immunity. Its interaction with CD40, its classical receptor, is essential for B cell activation, proliferation, isotype switching, and germinal center formation. This interaction also plays a significant role in T cell priming and cell-mediated immune responses. In addition to CD40, CD154 can bind to several integrins, including αIIbβ3, α5β1, and αMβ2, which are involved in various inflammatory and immune processes. Abnormal expression of CD154 has been implicated in several autoimmune diseases, such as systemic lupus erythematosus (SLE), where it contributes to the overproduction of autoantibodies and inflammation.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy