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Description
Alexa Fluor® 488 Rat Anti-Mouse CD83 Antibody (S-R522)Product Specification Host Rat Antigen CD83 Synonyms CD83 antigen; mCD83; Cd83 Location Membrane Accession O88324 Clone Number S R522 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample LPS treated BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | CD83 |
| Synonyms | CD83 antigen; mCD83; Cd83 |
| Location | Membrane |
| Accession | O88324 |
| Clone Number | S-R522 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | LPS treated BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD83 is a 45-kDa, heavily glycosylated type I transmembrane glycoprotein of the immunoglobulin superfamily that functions as a key immune modulator: its membrane-bound form (mCD83) is a cardinal surface marker of fully mature dendritic cells and is also expressed on activated B and T lymphocytes, thymic epithelial cells, neutrophils and regulatory T cells, where it is essential for efficient antigen presentation, naïve T-helper-cell priming, thymic CD4⁺ T-cell selection, and the differentiation and stability of Foxp3⁺ Tregs, whereas the naturally shed soluble form (sCD83) acts as an immunosuppressive mediator that dampens DC maturation, drives macrophages toward an anti-inflammatory, alternative-activation phenotype via the LXR pathway, and has therapeutic potential in autoimmunity and transplantation.
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