Pay in installments of $37.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 26 - Aug 31
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Alexa Fluor® 488 Rat Anti-Mouse CD20 Antibody (S-R497)Product Specification Host Rat Antigen CD20 Synonyms B lymphocyte antigen CD20; B cell differentiation antigen Ly 44; Lymphocyte antigen 44; Membrane spanning 4 domains subfamily A member 1; Ly 44; Ms4a2; Ms4a1 Location Cell membrane Accession P19437 Clone Number S R497 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor
Product Specification
| Host | Rat |
| Antigen | CD20 |
| Synonyms | B-lymphocyte antigen CD20; B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; Ly-44; Ms4a2; Ms4a1 |
| Location | Cell membrane |
| Accession | P19437 |
| Clone Number | S-R497 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD20 is a 33-37 kDa non-glycosylated phosphoprotein expressed on the surface of B cells from the pre-B cell stage through maturity, but absent on plasma cells. It belongs to the MS4A protein family and has four transmembrane domains, one intracellular domain, and two extracellular loops. CD20 is believed to facilitate calcium influx, which is essential for B cell activation and proliferation. Although its exact biological function is not fully elucidated, studies suggest it plays a role in B cell receptor signaling and may act as a calcium channel. CD20 is a key therapeutic target for B cell malignancies and autoimmune diseases, as it is expressed on various B cell cancers and its targeting can induce cell death through mechanisms like complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy