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Description
p35/25 Recombinant Rabbit mAb (S-2719-47)Product Specification Host Rabbit Antigen p35 25 Synonyms Cyclin dependent kinase 5 activator 1; CDK5 activator 1; Cyclin dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; CDK5R; NCK5A; CDK5R1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession Q15078 Clone Number S 2719 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample Human brain, mouse brain,
Product Specification
| Host | Rabbit |
| Antigen | p35/25 |
| Synonyms | Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; CDK5R; NCK5A; CDK5R1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q15078 |
| Clone Number | S-2719-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human brain, mouse brain, rat brain |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| IF | 1:500 | Ms, Rt |
Background
p35/25 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5): p35 is the full-length, membrane-anchored protein that rapidly turns over and keeps CDK5 activity tightly controlled, whereas p25 is the calpain-cleaved, N-terminally truncated fragment that lacks the membrane-targeting myristoylation signal, relocates CDK5 to nuclear/perinuclear compartments, and—because of its 5- to 10-fold longer half-life—induces prolonged, deregulated CDK5 hyperactivity that aberrantly phosphorylates tau and other cytoskeletal proteins, thereby contributing to neurodegeneration in Alzheimer’s disease and related tauopathies.
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