Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 26 - Aug 31
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
EpCAM Recombinant Rabbit mAb,PBS Only (SDT-078-128)Product Specification Host Rabbit Antigen EpCAM Synonyms Epithelial cell adhesion molecule; Ep CAM; Adenocarcinoma associated antigen; Cell surface glycoprotein Trop 1; Epithelial cell surface antigen; Epithelial glycoprotein (EGP); Epithelial glycoprotein 314 (EGP314; hEGP314); CD326; GA733 2; M1S2; M4S1; MIC18; TACSTD1; TROP1 Immunogen Synthetic Peptide Location Cell membrane Accession P16422 Clone Number SDT 078 128 Antibody Type Recombinant mAb
Product Specification
| Host | Rabbit |
| Antigen | EpCAM |
| Synonyms | Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein (EGP); Epithelial glycoprotein 314 (EGP314; hEGP314); CD326; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P16422 |
| Clone Number | SDT-078-128 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HT-29, A431, HCT 116, T-47D, mouse colon, rat colon |
| Predicted Reactivity | Pg, Bv |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| ICC | 1:250 | Hu |
Background
EpCAM (epithelial cell adhesion molecule, CD326) is a 35–40 kDa type-I transmembrane glycoprotein expressed on most epithelia, where it first assembles into cis-dimers that further cluster into tetramers to support homotypic cell–cell contacts, and then—through sequential proteolytic cleavage—releases its intracellular domain (EpICD) that partners with β-catenin, FHL2 and LEF1 to enter the nucleus and drive Wnt-dependent transcription of genes controlling proliferation, stemness and epithelial-to-mesenchymal transition, thereby functioning not merely as an adhesion molecule but as a dynamic signaling hub that is highly up-regulated in most carcinomas, marks circulating tumor and cancer stem cells, and serves as both a prognostic biomarker and a therapeutic target while mutations that truncate or mis-localize the protein underlie the severe congenital diarrhea disorder tufting enteropathy.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy