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Description
Phospho-RIP (Ser166) Recombinant Rabbit mAb (S-2702-58)Product Specification Host Rabbit Antigen Phospho RIP (Ser166) Synonyms Receptor interacting serine threonine protein kinase 1; Cell death protein RIP; Receptor interacting protein 1 (RIP 1); Rinp; Rip; Ripk1 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession Q60855 Clone Number S 2702 58 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Phospho-RIP (Ser166) |
| Synonyms | Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP; Receptor-interacting protein 1 (RIP-1); Rinp; Rip; Ripk1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | Q60855 |
| Clone Number | S-2702-58 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
Phospho-RIP (Ser166) is the phosphorylated form of receptor-interacting protein kinase 1 (RIPK1) at serine 166, a modification that acts as a biomarker for the kinase’s activation and marks the initiation of RIPK3/MLKL-dependent necroptotic signaling; this phosphorylation event converts RIPK1 from a pro-survival scaffold into a death-inducing kinase, enabling assembly of the necrosome complex (RIPK1–RIPK3–MLKL) that drives inflammatory, caspase-independent cell death, and its detection is therefore widely used to monitor necroptotic activity in cancer, neurodegeneration and inflammatory disease research.
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