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Description
SLC10A1/NTCP1 Recombinant Rabbit mAb (S-2844-23)Product Specification Host Rabbit Antigen SLC10A1 NTCP1 Synonyms Hepatic sodium bile acid cotransporter; Cell growth inhibiting gene 29 protein; Na(+) bile acid cotransporter; Na(+) taurocholate transport protein; Sodium taurocholate cotransporting polypeptide (NTCP6 Publications); Solute carrier family 10 member 1 (SLC10A1); NTCP Immunogen Synthetic Peptide Location Cell membrane Accession Q14973 Clone Number S 2844 23 Antibody Type Recombinant mAb
Product Specification
| Host | Rabbit |
| Antigen | SLC10A1/NTCP1 |
| Synonyms | Hepatic sodium/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide (NTCP6 Publications); Solute carrier family 10 member 1 (SLC10A1); NTCP |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q14973 |
| Clone Number | S-2844-23 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, Caco-2, mouse kidney, mouse liver, rat kidney, rat liver |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
Background
The SLC10A1 gene encodes the sodium/bile acid cotransporter NTCP1, a 349-amino-acid, 7-transmembrane-domain glycoprotein that is almost exclusively expressed on the basolateral membrane of hepatocytes, where it uses the inward Na⁺ gradient to mediate high-affinity uptake of conjugated bile acids and, notably, also serves as the principal entry receptor for hepatitis B and D viruses, while additional substrates including steroid sulfates, thyroid hormones, and certain drugs link NTCP1 to systemic bile acid homeostasis, lipid metabolism, and pharmacokinetics, and inherited or acquired dysregulation of the transporter produces cholestatic disorders that are increasingly targeted by small-molecule or siRNA therapeutics.
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