Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 9 - Jul 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
TACC3 Recombinant Rabbit mAb (S-3048-50)Product Specification Host Rabbit Antigen TACC3 Synonyms Transforming acidic coiled coil containing protein 3; ERIC 1; ERIC1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession Q9Y6A5 Clone Number S 3048 50 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample RPMI 8226, HeLa, Raji, Ramos, mouse testis, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | TACC3 |
| Synonyms | Transforming acidic coiled-coil-containing protein 3; ERIC-1; ERIC1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | Q9Y6A5 |
| Clone Number | S-3048-50 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | RPMI-8226, HeLa, Raji, Ramos, mouse testis, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a centrosomal and microtubule-associated protein essential for bipolar spindle assembly and chromosome segregation during mitosis and meiosis. It stabilizes microtubules by forming a complex with ch-TOG (CKAP5) and clathrin, promoting kinetochore-microtubule attachments and preventing spindle multipolarity. TACC3 is frequently overexpressed or involved in oncogenic fusions like FGFR3-TACC3 in various cancers, including bladder, pancreatic, and colorectal cancers, where it drives proliferation, immune evasion, and chemoresistance. Its overexpression disrupts DNA damage response pathways and sensitizes cells to PARP inhibitors, while its depletion induces mitotic catastrophe and cell cycle arrest, making it a promising therapeutic target in oncology.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy