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Description
LGR4 Recombinant Rabbit mAb (S-2787-39)Product Specification Host Rabbit Antigen LGR4 Synonyms Leucine rich repeat containing G protein coupled receptor 4; G protein coupled receptor 48; GPR48 Immunogen Synthetic Peptide Location Cell membrane Accession Q9BXB1 Clone Number S 2787 39 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | LGR4 |
| Synonyms | Leucine-rich repeat-containing G-protein coupled receptor 4; G-protein coupled receptor 48; GPR48 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q9BXB1 |
| Clone Number | S-2787-39 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
LGR4 (Leucine-rich repeat-containing G-protein-coupled receptor 4) is a 951-amino-acid, 7-transmembrane glycoprotein that belongs to the B subgroup of the LGR family, distinguished by an extracellular domain with 17 leucine-rich repeats; it is broadly expressed in heart, brain, liver, kidney, endocrine and reproductive organs and serves as the principal receptor for R-spondins (RSPO1-4), which potentiate Wnt/β-catenin signaling by coupling LGR4 to the E3 ligases ZNRF3/RNF43, thereby stabilizing β-catenin and driving transcriptional programs essential for eye, kidney, bone, skin, tooth, gonad, hematopoietic, digestive and metabolic development, while also modulating NF-κB, TGF-β and other pathways to protect hepatocytes, regulate myogenesis, hematopoiesis and steroidogenesis, and its germ-line loss-of-function mutations in humans cause osteoporosis, low body weight, hypoglycemia and electrolyte imbalance, and conditional deletion in mice produces severe renal hypoplasia, underscoring its systemic role as a master regulator of organogenesis and metabolic homeostasis.
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