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Description
CENPB Recombinant Rabbit mAb (S-1713-209)Product Specification Host Rabbit Antigen CENPB Synonyms Major centromere autoantigen B; Centromere protein B (CENP B) Immunogen Synthetic Peptide Accession P07199 Clone Number S 1713 209 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample A431 Predicted Reactivity Hm Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA,
Product Specification
| Host | Rabbit |
| Antigen | CENPB |
| Synonyms | Major centromere autoantigen B; Centromere protein B (CENP-B) |
| Immunogen | Synthetic Peptide |
| Accession | P07199 |
| Clone Number | S-1713-209 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | A431 |
| Predicted Reactivity | Hm |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
CENPB protein, which stands for centromere protein B, is a crucial component of the centromere, a specialized region on chromosomes. It plays a vital role in ensuring proper chromosome segregation during cell division. CENPB is involved in the formation and maintenance of centromeric chromatin, helping to establish and stabilize the structure of the centromere. This protein also aids in the recruitment of other essential centromere-associated proteins, thereby facilitating the assembly of the kinetochore, a complex protein structure that forms on the centromere and is essential for the attachment of spindle microtubules during mitosis and meiosis. Mutations or abnormalities in CENPB can lead to chromosomal instability and are associated with various genetic disorders and cancers.
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