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Description
ARL13B Recombinant Rabbit mAb (S-2113-11)Product Specification Host Rabbit Antigen ARL13B Synonyms ADP ribosylation factor like protein 13B; ADP ribosylation factor like protein 2 like 1 (ARL2 like protein 1); ARL2L1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane Accession Q3SXY8 Clone Number S 2113 11 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Positive Sample HeLa, HEK 293, 293T, NCCIT Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | ARL13B |
| Synonyms | ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1 (ARL2-like protein 1); ARL2L1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Cell membrane |
| Accession | Q3SXY8 |
| Clone Number | S-2113-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HEK-293, 293T, NCCIT |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200-1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
| IF | 1:500 | Rt |
Background
ARL13B, also known as ADP-ribosylation factor-like protein 13B, is a small GTPase belonging to the ADP-ribosylation factor family and the Ras superfamily of GTPases. It is encoded by the ARL13B gene in humans and is predominantly localized in primary cilia. This protein plays a crucial role in cilia formation and maintenance. Mutations in the ARL13B gene can lead to Joubert syndrome, a ciliopathy characterized by brain malformations, polydactyly, and renal cyst formation. ARL13B is also involved in regulating intraflagellar transport and the localization of other proteins within the cilium, such as Smoothened (Smo), which is essential for Sonic hedgehog (Shh) signaling. Additionally, ARL13B has been found to promote the proliferation, migration, and osteogenesis of osteoblasts, suggesting its potential role in bone formation and mechanosensation.
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