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Description
Human IGF-1 OneStep ELISA KitProduct Specification Antigen IGF 1 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Kit Precision Intra assay: 4. 2% Inter assay: 7. 7% Sample type Cell culture supernatant, Serum, Plasma Assay type Sandwich (quantitative) Sensitivity 0. 054 ng ml Range 0. 47 ng mL 30 ng mL Recovery Cell culture supernatant: 99%
Product Specification
| Antigen | IGF-1 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Kit
| Precision | Intra-assay: 4.2%； Inter-assay: 7.7% |
| Sample type | Cell culture supernatant, Serum, Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.054 ng/ml |
| Range | 0.47 ng/mL – 30 ng/mL |
| Recovery | Cell culture supernatant: 99% Serum: 106% Plasma: 110% |
| Assay time | 60 minutes |
| Species reactivity | Human |
Background
Human Insulin-like Growth Factor-1 (IGF-1) is a 7.6 kDa polypeptide hormone structurally similar to insulin, playing a crucial role in growth, development, and metabolic regulation. Primarily produced in the liver under stimulation by growth hormone (GH), IGF-1 mediates many of GH's anabolic and mitogenic effects via activation of the IGF-1 receptor (IGF-1R), a tyrosine kinase receptor that triggers downstream signaling pathways such as PI3K/AKT and MAPK/ERK. IGF-1 is essential for: Growth & Development: Promotes cellular proliferation, differentiation, and tissue growth, particularly in bone, muscle, and nervous systems. Metabolic Regulation: Enhances glucose uptake, protein synthesis, and inhibits apoptosis. Tissue Repair: Supports regeneration in muscle, cartilage, and neuronal tissues. Clinically, recombinant human IGF-1 (rhIGF-1, e.g., mecasermin) is used to treat growth disorders like Laron syndrome and severe primary IGF-1 deficiency. It is also investigated for conditions such as diabetes, neurodegenerative diseases, and muscle wasting disorders. However, its dysregulation is associated with cancer progression and acromegaly.
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