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Description
CEACAM-8/CD66b His Tag Protein, HumanProduct Specification Species Human Synonyms CEACAM8, CD66b, CD67, CGM6, NCA 95 Accession P31997 Amino Acid Sequence Gln35 Asp320, with C terminal 8*His QLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDGGGSHHHHHHHH
Product Specification
| Species | Human |
| Synonyms | CEACAM8, CD66b, CD67, CGM6, NCA-95 |
| Accession | P31997 |
| Amino Acid Sequence | Gln35-Asp320, with C-terminal 8*His QLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Yoon J. et al. (2007) CD66b regulates adhesion and activation of human eosinophils. J Immunol. 179(12): 8454-8462. 2、Skubitz K M. et al. (1996) CD6a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J Leukoc Biol. 60(1): 106-117. 3、Skubitz K M. et al. (2008) Inte rdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells. J Transl Med. 6: 78. 4、Lasa A. et al. (2008) High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias. Ann Hematol. 87(3): 205-211. |
Background
Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM-8), also known as CGM6 and CD66b, is an approximately 95 kDa member of the human carcinoembryonic antigen (CEA) family that plays a role in cell adhesion, cell migration and pathogen binding. Human CEACAM-8 is composed of a 34 amino acid (aa) signal peptide, a 29 aa propeptide segment which is removed in the mature form, and a 286 aa CEACAM-8 region containing one V-type and two C2-type Ig-like domains. CEACAM family members are widely expressed in epithelial, endothelial, and hematopoietic cells, including neutrophils, T-cells, and NK cells. CEACAMs appear to be capable of transmitting signals that result in a variety of effects depending on the tissue, including tumor suppression, tumor promotion, angiogenesis, neutrophil activation, lymphocyte activation, regulation of the cell cycle, and regulation of adhesion. CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis.
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4.6 ★★★★★
Based on 7 reviews
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Product Reviews
★★★★★ 5
Nice toy for a bigger dog
Color: Gray, Size: 6 IN
My little rescue chihuahua has exactly one toy he can make squeak. This one is cute and he did try, but no luck. I have two large baskets of toys I've bought in the 3 years I've had him. He is only able to make one squeak. He loves it to death because he loves the squeak. It's a hedgehog that I will try to find on Amazon and replace. Poor little dog just has a very small mouth.
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Reviewed in the United States on June 3, 2026
★★★★★ 5
Semi durable
Color: Gray, Size: 8 IN
My dog has had this for 1 month, and it is still doing good! It has lost 3 out of 4 legs, but thw body is pretty strong. Dog loves the honk noises.
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Reviewed in the United States on March 7, 2026
★★★★★ 5
Luxurious Feel, Durable Build… but Full Rotation Privileges Have Been Revoked 💙🦴 🐾
Color: Blue, Size: 6 IN, Color: Blue, Size: 6 IN
🐾 Hi, I’m PVD; toy curator, plush critic & occasional chew sommelier.
This armadillo arrived beautifully packaged and immediately met my standards for texture, squeak clarity and cuddle factor. I originally gave it 5 stars for quality; and still do! But today I’m updating the review to reflect my current toy lifestyle rotation. 😌
What impressed me from day one:
✔️ High-end plush feel; soft enough to nap on, tough enough for energetic zoom bites and great relief from teething
✔️ Strong stitching; survived multiple “stress tests” (I chewed with intention)
✔️ HQ squeaker; not tinny or annoying, more of a honk
✔️ 6in is perfect size for small breeds; easy to carry during dramatic hallway walks
Why it now gets 4 stars from a seasoned toy collector:
✘ As my luxury toy collection expanded, this one gets grabbed less often
✘ Simple design; I now favor more interactive or complex textures
✘ Still “keep-worthy,” just no longer VIP spot on the chaise lounge
Best For:
• Pups who enjoy soft comfort toys or emotional support snuggles
• Light to moderate chewers
• Dogs who like to carry their plushes around proudly
• Ideal as a teething toy or thoughtful gift
🚫 Not ideal for: power chewers or highly stimulation-driven pups (like me now; my taste evolved)
📝 Final Re-Barks:
Still recommend for pups who love cuddly squeaky companions. Great starter plush and great quality; just know that ultra-picky toy enthusiasts may rotate it out once newer models (or squeakier friends) arrive.
— PVD (Plush Aficionado, Toy Rotation Director & High-Maintenance Household Icon) 🐶💁🏻♂️✨
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Reviewed in the United States on September 17, 2025
★★★★★ 4
Well Constructed Toy But Short-Life Squeaker
Color: Gray, Size: 8 IN
Super cute and durable toy. Makes a "grunting" noise that my dog loves. However rating a little lower because my dog has only been playing with it (gently) for a couple weeks and the grunting noise is starting to die. But she does really like this toy regardless!
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Reviewed in the United States on June 4, 2026
★★★★★ 5
Cute and soft dog toy!
Color: Gray, Size: 8 IN
This very cute armadillo dog toy is nice and soft for our Golden Retriever to carry around in his mouth. He eventually likes to pull off the legs, ears, or anything else extending from the body of the toy and so far he hasn’t been able to do so with this one. Not saying that it’s not possible, so as with any toy, you should monitor your dog playing with it as we definitely have to. He also likes to continually make his toys squeak and this toy’s squeaker works very well!
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Reviewed in the United States on June 4, 2026