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Description
BCRP/ABCG2 Recombinant Rabbit mAb (S-2365-67)Product Specification Host Rabbit Antigen BCRP ABCG2 Synonyms Broad substrate specificity ATP binding cassette transporter ABCG2; ATP binding cassette sub family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance associated protein; Placenta specific ATP binding cassette transporter; Urate exporter; CD338; ABCP; BCRP1; MXR Immunogen Recombinant Protein Location Mitochondrion, Cell membrane Accession Q9UNQ0 Clone Number S
Product Specification
| Host | Rabbit |
| Antigen | BCRP/ABCG2 |
| Synonyms | Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD338; ABCP; BCRP1; MXR |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion, Cell membrane |
| Accession | Q9UNQ0 |
| Clone Number | S-2365-67 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A549, PANC-1, mouse liver, rat liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
Background
The breast cancer resistance protein (BCRP/ABCG2), encoded by the ABCG2 gene, is a 655-amino-acid, 72–75 kDa half-transporter (a member of the ABC transporter superfamily G subfamily) that forms homodimers or oligomers to function as an ATP-dependent efflux pump actively transporting a broad range of substrates—including anticancer drugs (e.g., mitoxantrone, topotecan), endogenous compounds (e.g., estrone-3-sulfate, uric acid), and xenobiotics—across apical membranes of tissues such as the placenta, intestine, liver, kidney proximal tubules, and brain microvascular endothelium, thereby contributing to drug absorption, distribution, and elimination, protecting against xenobiotic exposure, and conferring multidrug resistance in cancer, particularly acute myeloid leukemia.
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