Pay in installments of $17.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 29 - Aug 3
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Akt (E17K Mutant Specific) Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Akt (E17K Mutant Specific) Synonyms RAC alpha serine threonine protein kinase; Protein kinase B (PKB); Protein kinase B alpha (PKB alpha); Proto oncogene c Akt; RAC PK alpha; PKB; RAC; AKT1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession P31749 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu Purification Immunogen Affinity Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | Akt (E17K Mutant Specific) |
| Synonyms | RAC-alpha serine/threonine-protein kinase; Protein kinase B (PKB); Protein kinase B alpha (PKB alpha); Proto-oncogene c-Akt; RAC-PK-alpha; PKB; RAC; AKT1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P31749 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
The AKT1(E17K mutant protein) is a constitutively active serine/threonine kinase generated by a single glutamate-to-lysine substitution at position 17 within its pleckstrin homology (PH) domain; this mutation creates new hydrogen bonds that markedly increase affinity for membrane phosphoinositides, driving persistent plasma-membrane localization and PI3K-independent phosphorylation of T308 and S473, thereby locking the kinase in an “always-on” conformation that fuels oncogenic signaling through mTORC1, GSK3β and FOXO, promotes cell survival, proliferation and migration, and confers both tumorigenic potential and resistance to many allosteric AKT inhibitors while remaining selectively targetable by emerging ATP-competitive or covalent mutant-specific inhibitors.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy