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Description
PD-1 Recombinant Rabbit mAb (SDT-035-25)Product Specification Host Rabbit Antigen PD 1 Synonyms CD279, PDCD1 Immunogen Synthetic Peptide Location Membrane Accession Q15116 Clone Number SDT 035 25 Antibody Type Rabbit mAb Application IHC P Reactivity Hu Purification Protein A Concentration 0. 5mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as
Product Specification
| Host | Rabbit |
| Antigen | PD-1 |
| Synonyms | CD279, PDCD1 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q15116 |
| Clone Number | SDT-035-25 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 |
Background
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
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4.2 ★★★★★
Based on 23 reviews
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Product Reviews
★★★★★ 5
My Niece dog loves it!
Size: 18in, Style: Sport
This ball launcher takes a bit of getting. used to, but it is really helpful for those of us who are not MLB pitchers! The launcher itself is a sturdy plastic that is not brittle yet not soft; when the ball is launched there is no destructive bending in the shaft. The handle is padded and ergonomically sound while the cup end cradles the ball but has cut-outs on each side for easy loading and unloading of the ball. It did take a bit of practice for me to get the hang of it, but for my husband and son it was much easier. The launcher works well to help us older, non-gifted athletes launch the ball farther and faster while saving the shoulder, elbow, and wrist (important if there is any arthritis). The ball fits nicely into the cup and releases easily.
The 2.5 size was too small for my Doberman, so we opted for the 3.5 in launcher. This smaller launcher and ball are now in the employ of my sister and her husband for their retriever-border collie mix, an 18 month old little fireball!. This is just the right size for her. My sister's husband has difficulty with arthritis and is neither quick on his feet nor able to stand very long. So the launcher comes in very handy. He can actually sit in a lawn chair and throw the ball repeatedly when their dog retrieves and returns it to him. That is a win- win!
Top 3 Likes:
-Easy to use
-Helps older pet owner
-Drives the ball farther and faster
Top 3 Dislikes:
-With repeated uses the edges of the launcher appear to get scuffed and scratched
-Some ingrained staining on the edges persists requiring scrubbing to remove
-There is a mild worry that with time the launcher may snap
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Reviewed in the United States on September 4, 2024
★★★★★ 5
My dog loves it
Size: 25in, Style: Sport
I am amazed at how far I can throw a tennis ball. My dog and I absolutely love this. What happens to work well with the squeaky balls?I get on amazon as well. I have one of these at home, And I keep another one in the truck.
Very durable, The balls have good bounce, My dog and I have a lot of fun with it. My dog doesn't chew much on balls, But this one seems like it's going to stand out, I love the versatility, Hey can handle almost ending ball that same size. Are you solid rubber bouncy balls, Squeak.
Ing tuba balls, Whiffle balls with all the holes in it, Even the squeaky chewing balls. As long as there are that same size.
love the product. I've been using them for a few years.
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Reviewed in the United States on July 22, 2024
★★★★★ 5
Great product
Style: Sport, Size: Large
This is a lifesaver. My lab will chase the ball all day and this saves the arms and shoulders. A little bit of a learning curve to use but I would definitely recommend
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Reviewed in the United States on May 24, 2026
★★★★★ 5
Labs love this!!!
Style: Sport, Size: Large
Our Lab LOVES everything about this thing! Recommend getting extra durable balls as the 1 included fell apart in 1 hour. I have a very energetic Lab retriever that we have to force to stop playing ball so he does not overheat. That & the force with which you can throw this ball did not help keeping it from splitting it in 2 in less than 1 hour.
This is worth the money for the extra throwing power & distance but do invest in the ULTRA strong ball for dogs like retrievers! Also, be sure to order the correct SIZE OF BALL, specific to each different size of throwing wand.
My fav thing about this item is #1 the joy my dog gets from the new challenge of racing to catch longer throws, & #2 I don't have to get my hands covered in dog slobber!!
He has gotten to where he can almost put it in the cup himself so I won't waste time throwing the ball again!
Man, I love that dog!!! ❤️
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Reviewed in the United States on November 1, 2023
★★★★★ 5
Must-Have for Active Dogs!
Style: Sport, Size: Large
The Chuckit Sport 26L Dog Ball Launcher has been a game-changer for my large dog! My 80-pound Labrador loves to play fetch, and this launcher makes it so much easier and more enjoyable for both of us.
The 26” length gives me the leverage to throw the ball much farther than I could by hand, which really helps burn off my dog’s energy. The included large ball (3”) is the perfect size for big dogs, and I appreciate that it’s made from durable rubber, so it withstands a lot of chewing and rough play.
What I really love is that the launcher is so lightweight and easy to use. I can play fetch with my dog for extended periods without my arm getting tired. The ergonomic handle also provides a comfortable grip, which is a nice touch.
If you have a large, active dog, the Chuckit Sport 26L is a must-have. It’s well-made, durable, and makes fetch more fun for both you and your dog. Highly recommend!
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Reviewed in the United States on September 3, 2024