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Description
PHGDH Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen PHGDH Synonyms D 3 phosphoglycerate dehydrogenase; 3 PGDH; 2 oxoglutarate reductase; Malate dehydrogenase; PGDH3 Immunogen Synthetic Peptide Location Cytoplasm Accession O43175 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, MCF7, NIH 3T3, mouse brain, C6 Predicted Reactivity Bv, CyMk, Cz, Or, Pg Purification Immunogen Affinity Concentration Lot
Product Specification
| Host | Rabbit |
| Antigen | PHGDH |
| Synonyms | D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; PGDH3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | O43175 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, MCF7, NIH/3T3, mouse brain, C6 |
| Predicted Reactivity | Bv, CyMk, Cz, Or, Pg |
| Purification | Immunogen Affinity |
| Concentration | Lot specific* (generally 0.5 to 2 mg/ml) |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
PHGDH (Phosphoglycerate Dehydrogenase) protein is a key enzyme involved in the metabolic pathway that converts 3-phosphoglycerate to phosphohydroxypyruvate. It plays a crucial role in serine biosynthesis, which is essential for various cellular processes including the production of nucleotides, lipids, and antioxidants. Abnormal expression of PHGDH has been implicated in several diseases, particularly in cancer, where its upregulation can promote tumor growth and survival by supporting biosynthetic demands and redox homeostasis. Additionally, PHGDH has been identified as a potential therapeutic target in certain cancer types due to its role in maintaining cancer cell metabolism.
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