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Description
EGR1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen EGR1 Synonyms Early growth response protein 1; EGR 1; AT225; Nerve growth factor induced protein A (NGFI A); Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox 24; KROX24; ZNF225 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P18146 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive
Product Specification
| Host | Rabbit |
| Antigen | EGR1 |
| Synonyms | Early growth response protein 1; EGR-1; AT225; Nerve growth factor-induced protein A (NGFI-A); Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24; KROX24; ZNF225 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P18146 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa treated with TNF-α, NIH/3T3, mouse brain |
| Predicted Reactivity | Bv |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
EGR1 protein, also known as Early Growth Response 1 or NGFI-A, is a mammalian transcription factor encoded by the EGR1 gene. It belongs to the EGR family of Cys2His2-type zinc finger proteins and acts as a nuclear protein regulating transcription. EGR1 plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. It is involved in the regulation of multiple genes, some of which are tumor suppressors like TGFβ1, p53, and PTEN. However, its role in cancer is complex; while it is overexpressed in some cancers like colorectal and gastric cancer, leading to poor prognosis, it also acts as a tumor suppressor in others, such as rhabdomyosarcoma. Additionally, EGR1 is implicated in neuronal plasticity and cardiovascular diseases.
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