Pay in installments of $18.75 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 9 - Aug 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
APC-Cy7 Rat Anti-Mouse CD8α Antibody (S-R540)Product Specification Host Rat Antigen CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T cell surface glycoprotein Lyt 2; CD8a; Lyt 2; Lyt2 Location Cell membrane Accession P01731 Clone Number S R540 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation APC Cy7 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Rat |
| Antigen | CD8α |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; CD8a; Lyt-2; Lyt2 |
| Location | Cell membrane |
| Accession | P01731 |
| Clone Number | S-R540 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | APC-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD8α is a crucial immune glycoprotein that plays a key role in coordinating immune responses against both external and internal threats. It serves as a co-receptor for the MHC class I-peptide complex, facilitating the recognition of antigens derived from cytosolic proteins by T cells. CD8α can form either a homodimer (CD8αα) or a heterodimer with CD8β (CD8αβ), both of which interact with the T cell receptor (TCR) and MHC class I molecules to recruit the LCK kinase and initiate multiple signaling pathways. This interaction is essential for the activation of cytotoxic T lymphocytes (CTLs), which are critical for eliminating infected or abnormal cells. Additionally, CD8α is involved in the development and function of intraepithelial lymphocytes (IELs) in the gut, contributing to the maintenance of mucosal barriers.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy