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Description
FITC Rat anti-Mouse CD8α Antibody (S-R381)Product Specification Host Rat Antigen mouse CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T cell surface glycoprotein Lyt 2; Lyt 2; Lyt2 Location Cell membrane Accession P01731 Clone Number S R381 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 02mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0.
Product Specification
| Host | Rat |
| Antigen | mouse CD8α |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; Lyt-2; Lyt2 |
| Location | Cell membrane |
| Accession | P01731 |
| Clone Number | S-R381 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.02mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD8A, also known as CD8 or T-cell surface glycoprotein CD8 alpha chain, is a crucial integral membrane glycoprotein predominantly found on cytotoxic T lymphocytes. It functions as a coreceptor, aiding the T-cell receptor (TCR) in recognizing antigens presented by antigen-presenting cells (APCs) in the context of MHC class I molecules. This interaction is vital for the activation of cytotoxic T-lymphocytes (CTLs), which can then identify and eliminate infected or tumor cells. CD8A can exist as a homodimer of two alpha chains or as a heterodimer with a beta chain, both forms sharing significant homology to immunoglobulin variable light chains. The protein is also involved in intracellular signaling pathways, leading to lymphokine production, motility, adhesion, and activation of CTLs. Additionally, CD8A has been implicated in various diseases and is classified as a disease-related gene.
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