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Description
Mouse CCL11/Eotaxin OneStep ELISA KitProduct Specification Antigen CCL11 Eotaxin Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Ms Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 9% Inter assay: 4. 8% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 5. 489 pg mL Range 15. 63 pg mL 1000 pg mL Recovery Cell culture
Product Specification
| Antigen | CCL11/Eotaxin |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Ms |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.9%； Inter-assay: 4.8% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 5.489 pg/mL |
| Range | 15.63 pg/mL – 1000 pg/mL |
| Recovery | Cell culture supernatant: 111% Serum: 106% Plasma: 102% |
| Assay time | 60 minutes |
| Species reactivity | Ms |
Background
CCL11, commonly known as eotaxin-1, is a small chemokine protein that plays a critical role in the immune system. Its primary function is to recruit eosinophils, a specific type of white blood cell, to sites of inflammation by binding to the CCR3 receptor on their surface. This action makes CCL11 a key player in allergic responses and the pathogenesis of diseases like asthma. Beyond its role in immunity, recent research has revealed a surprising connection to the aging process, as elevated levels of CCL11 have been linked to impaired neurogenesis and cognitive decline. Produced by various cells including endothelial cells and fibroblasts, it is also implicated in other chronic inflammatory conditions and certain cancers. Consequently, therapeutic strategies aimed at blocking CCL11 signaling are being actively investigated for treating a range of disorders from allergies to age-related cognitive deficits.
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