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Description
Glycoprotein/GP RBD Fc Chimera Protein, Ebola virusProduct Specification Species Ebola virus Synonyms Glycoprotein GP RBD Protein (EBOV) Accession AHX24649 Amino Acid Sequence Met1 Phe308 with hFc Tag at the C Terminus Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 90% by SDS PAGE Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Ebola virus |
| Synonyms | Glycoprotein/GP-RBD Protein (EBOV) |
| Accession | AHX24649 |
| Amino Acid Sequence | Met1-Phe308 with hFc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Hood CL, et al. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar;84(6):2972-82. |
Background
The fourth gene of the Ebola virus (EBOV) encodes the glycoprotein GP, a multidomain and multifunctional class I fusion protein. It exists as trimers on the viral surface and mediates viral entry through a heterodimer of GP1 and GP2 subunits generated by furin cleavage. GP1 facilitates infection via its receptor-binding domain (RBD), which interacts with key host receptors such as TIM-1 and NPC1, while its mucin-like domain—modified by glycosylation—enhances infectivity and shields neutralization epitopes. GP2 drives membrane fusion and nucleocapsid release. Additionally, GP exhibits significant immunomodulatory functions: it downregulates integrin expression to disrupt vascular integrity, activates monocytes/macrophages via the TLR4 pathway triggering a cytokine storm, counteracts the antiviral effects of BST2, and acts as a decoy to evade antibody neutralization. These mechanisms collectively promote immune evasion and contribute to viral pathogenesis.
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