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Description
eIF2α Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen eIF2 Synonyms Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha (eIF 2 alpha; eIF 2A; eIF 2alpha; eIF2 alpha); EIF2A; EIF2S1 Immunogen Synthetic Peptide Location Cytoplasm, Mitochondrion Accession P05198 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample PC 3, MCF7, Ramos, HepG2, NIH 3T3, PC 12, COS
Product Specification
| Host | Rabbit |
| Antigen | eIF2α |
| Synonyms | Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha); EIF2A; EIF2S1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Mitochondrion |
| Accession | P05198 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | PC-3, MCF7, Ramos, HepG2, NIH/3T3, PC-12, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
eIF2α (eukaryotic initiation factor 2 subunit alpha) is a 35 kDa phosphoprotein that, together with the G-protein βγ dimer eIF2B, forms the heterotrimeric eIF2 complex essential for delivering the initiator methionyl-tRNA to the 40S ribosomal subunit in a GTP-dependent manner; phosphorylation of Ser51 by stress-sensing kinases (PKR, PERK, HRI, GCN2) converts eIF2 into a non-competitive inhibitor of its guanine-nucleotide-exchange factor eIF2B, thereby repressing global cap-dependent translation while selectively permitting ATF4 and other stress-response mRNAs, a switch that underlies cellular adaptation to starvation, oxidative stress, viral infection, and proteotoxicity, and whose dysregulation contributes to diseases ranging from neurodegeneration and cancer to diabetes and viral pathogenesis.
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