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Description
Invivo anti-human CD47 Recombinant mAbProduct Specification Host Mouse Antigen CD47 Synonyms Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin associated protein (IAP); Protein MER6; MER6 Location Cell membrane Accession Q08722 Clone Number S 3901 Antibody Type Mouse mAb Isotype IgG1,k Application ELISA, WB, in vitro CD47 neutralization, in vivo CD47 neutralization in human tumor xenograft models or humanized mice Reactivity Hu Purification Protein G
Product Specification
| Host | Mouse |
| Antigen | CD47 |
| Synonyms | Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein (IAP); Protein MER6; MER6 |
| Location | Cell membrane |
| Accession | Q08722 |
| Clone Number | S-3901 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ELISA, WB, in vitro CD47 neutralization, in vivo CD47 neutralization in human tumor xenograft models or humanized mice |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
CD47, also known as integrin-associated protein, is a ubiquitously expressed cell surface receptor that belongs to the immunoglobulin superfamily. It is widely known for its role in preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein alpha (SIRPα) on phagocytic cells. This “don’t eat me” signal is crucial for the survival of healthy cells, but cancer cells often overexpress CD47 to evade immune attack. In addition to its role in immune regulation, CD47 is involved in various cellular processes, including cell adhesion, migration, and the regulation of autophagy and cell death. For instance, it can regulate the migration of immune cells like neutrophils and dendritic cells, and its interaction with thrombospondin-1 (TSP-1) can induce apoptosis in certain cell types. Due to its significant role in cancer immunotherapy, CD47 has become an important target for developing new therapeutic strategies.
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