Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 25 - Aug 30
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
SS18-SSX Recombinant Rabbit mAb (SDT-4202)Product Specification Host Rabbit Antigen SS18 SSX Synonyms SYT SSX1; SS18 SSX1 fusion; SSX1 SSXT fusion Location Nucleus Accession A4PIV8 Clone Number SDT 4202 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | SS18-SSX |
| Synonyms | SYT-SSX1; SS18/SSX1 fusion; SSX1/SSXT fusion |
| Location | Nucleus |
| Accession | A4PIV8 |
| Clone Number | SDT-4202 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
Background
The SS18-SSX fusion protein is the defining oncogenic driver of synovial sarcoma, arising from the chromosomal translocation t(X;18)(p11;q11) that fuses the SS18 gene on chromosome 18 with SSX1, SSX2, or rarely SSX4 on the X chromosome, producing a chimeric protein in which the C-terminal 8 amino acids of SS18 are replaced by 78 residues from SSX; this fusion retains the N-terminal SNH domain of SS18 that mediates incorporation into SWI/SNF (BAF) chromatin-remodeling complexes, but the SSX moiety recruits polycomb repressive complexes (especially PRC1.1 via KDM2B) and binds H2AK119ub-rich regions, thereby hijacking BAF targeting to aberrantly activate developmentally repressed genes, evict the tumor-suppressive BAF47 (SMARCB1/INI1) subunit, and globally reprogram the epigenetic landscape to enforce malignant transformation.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy