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Description
Alexa Fluor® 488 Mouse Anti-Human CD109 Antibody (S-3080)Product Specification Host Mouse Antigen CD109 Synonyms CD109 antigen; 150 kDa TGF beta 1 binding protein; C3 and PZP like alpha 2 macroglobulin domain containing protein 7; Platelet specific Gov antigen; p180; r150; CPAMD7 Location Cell membrane Accession Q6YHK3 Clone Number S 3080 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human peripheral blood leukocytes Purification Protein G Concentration 0. 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD109 |
| Synonyms | CD109 antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Platelet-specific Gov antigen; p180; r150; CPAMD7 |
| Location | Cell membrane |
| Accession | Q6YHK3 |
| Clone Number | S-3080 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein of ~162 kDa that belongs to the α2-macroglobulin/complement thioester-containing protein superfamily and functions as a multifunctional co-receptor and negative regulator of transforming growth factor-β (TGF-β) signaling by physically interacting with TGF-β receptors, promoting their internalization and degradation via SMAD7/Smurf2-dependent pathways, as well as by releasing a soluble fragment that sequesters TGF-β ligand; it is expressed on activated T cells, platelets, basal epithelial, myoepithelial and hematopoietic progenitor cells, and is dysregulated in numerous squamous cell carcinomas and adenocarcinomas, where it modulates inflammation, epithelial-to-mesenchymal transition, cancer stemness, metastasis and immune responses by crosstalking with the TGF-β, NF-κB, JAK/STAT3 and YAP pathways, thereby serving as both a prognostic biomarker and a potential therapeutic target in malignancies and inflammatory diseases .
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Exchange/Return Notes
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