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Description
CD72 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD72, LYB2, CD72b, Lyb2 Accession P21854 Amino Acid Sequence Arg117 Asp359, with C terminal human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | CD72, LYB2, CD72b, Lyb2 |
| Accession | P21854 |
| Amino Acid Sequence | Arg117-Asp359, with C-terminal human IgG1 Fc RYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 59-68kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Wu H J. et al. (2009) CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function. J Clin Immunol. 29: 12-21. 2、Adachi T. et al. (1998) The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol. 160: 4662-4665. 3、Adachi T. et al. (2000) CD72 negatively regulates signaling through the antigen receptor of B cells. J Immunol. 164: 1223-1229. |
Background
CD72 is a coreceptor of B cell receptor (BCR), which is expressed on all B cells starting at the pre-B cell stage, but its expression decreases significantly during differentiation into plasma cells. CD72 is a transmembrane receptor that is expressed as a homodimer. It has a conserved intracellular domain, which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds SHP-1, a tyrosine phosphatase, and an ITIM-like motif that binds Grb2, an adaptor protein required to activate the Ras pathway. CD72 is known to play an important role in various B cell processes, including proliferation, apoptosis and differentiation. Mouse CD72 negatively regulates BCR signaling by recruiting Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) at ITIM.
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4.6 ★★★★★
Based on 12 reviews
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Product Reviews
★★★★★ 5
Great purchase! Will Buy Again.
Color: A01-Colorful Pink
Best purchase for my childs tablet. They are able to carry it like a cross-body with the strap or hold it with the handle. The handle is able to rotate in different directions to set up hands free on a table either longer way (landscape) or short (portrait). It has a hard case then the thicker silicone surrounding it. It does a great job protecting the tablet. My little one has dropped it plenty of times and it's still in great condition.
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Reviewed in the United States on March 23, 2026
★★★★★ 5
Super durable
Color: A01-Colorful Pink
Super durable and nice love it especially to protect the iPad!
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Reviewed in the United States on May 12, 2026
★★★★★ 5
So far, indestructible.
Color: Coral Orange
Such a good case! For a 6 year old that isn’t exactly gentle with devices, it’s perfect. The swivel kick stand is pretty versatile, easy to find a comfortable angle to see the screen no matter which weird position your kid sits in. The color is really nice, the orange is soft and very pretty.
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Reviewed in the United States on March 5, 2026
★★★★★ 4
Sturdy just wish it could be adjusted to hang shorter
Color: A01-Colorful Pink
Very sturdy. Love the colors, easy for my 4 yr old to handle and use.
Wish the length could be adjusted shorter for her though. When wearing, it tends to hang low by her knees.
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Reviewed in the United States on July 20, 2025
★★★★★ 5
Very reliable, even after 1 year!
Color: A01-Colorful Pink
I purchased this over a year ago. It has since been dropped, stood on and thrown (all by toddlers) and no visible damage whatsoever! I love the kickstand that also double has a way to hold while moving. It's a bit complicated to initially put together, just because of all the placement of the silicone around the plastic box, but once every bit is in the right place you're golden. I also appreciate the port cover to add an even higher durability rating from me. My toddlers find this very easy to use and I love how versatile it all is. Definitely worth the money to keep the iPads running and protected.
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Reviewed in the United States on May 16, 2026