SKU: 82283611912

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)

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Description

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)Product Specification Host Rabbit Antigen ALK Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246 Location Cell membrane Accession Q9UM73 Clone Number SDT 3284 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, IMR 32 Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of

Product Specification


Host Rabbit
Antigen ALK
Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246
Location Cell membrane
Accession Q9UM73
Clone Number SDT-3284
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample SH-SY5Y, IMR-32
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu

Background

Anaplastic lymphoma kinase (ALK), also designated CD246, is a single-pass transmembrane receptor tyrosine kinase of the insulin-receptor superfamily that is normally expressed at highest levels in the developing and adult nervous system, where it regulates neuronal differentiation, axon guidance and cognition; the 1620-aa glycoprotein presents an N-terminal extracellular region containing two MAM domains and an LDL-A module for ligand binding, a single hydrophobic transmembrane segment and a C-terminal cytoplasmic kinase domain that, upon ligand-induced dimerization, undergoes trans-autophosphorylation and triggers RAS–MAPK, PI3K–AKT and JAK–STAT signaling cascades controlling cell proliferation and survival. Chromosomal translocations (most famously t(2;5)(p23;q35) producing NPM1–ALK), inversions (EML4–ALK in non-small-cell lung cancer) or activating point mutations cause constitutive kinase activity, driving malignant transformation in anaplastic large-cell lymphoma, subsets of NSCLC, neuroblastoma and inflammatory myofibroblastoma, making the oncoprotein a validated therapeutic target for small-molecule inhibitors such as crizotinib, alectinib and lorlatinib.

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SKU: 82283611912

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4.8 ★★★★★
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haley kouba
Massapequa, US
★★★★★ 2
Not good for sun protection
Color: #2 ROSE
Product smells good and leaves skin glowing and soft however the sun protection isn’t great. I’m someone who reapplies every 90 minutes like clockwork, everywhere and not just where the sun shines, and I’ve used this three times now and burned each time.
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Reviewed in the United States on July 2, 2025
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Luke Sorensen
Massapequa, US
★★★★★ 5
Perfect After-Sun Lotion
This lotion feels amazing after being out in the sun all day. It keeps my skin soft and hydrated without feeling greasy, and the scent is light and tropical. I also love the subtle glow it gives my skin. Great size for keeping in a beach bag or taking on vacation. Definitely recommend if you want your tan to last longer and your skin to feel moisturized.
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Reviewed in the United States on May 13, 2026
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JD
Lake Worth, US
★★★★★ 5
Smells Devine
I got this Hawaiian Tropic After Sun Lotion to use after long beach days this past summer, and it quickly became part of my routine. It feels soothing on the skin after sun exposure and absorbs nicely without leaving a greasy layer. What I noticed most is how well it helps maintain my tan. My color seemed to last longer and fade more evenly when I consistently used it. I even saw a difference when I was using tanning beds — my skin looked more hydrated, which made the tan appear richer and less patchy. The scent is another highlight. It has that classic tropical fragrance that instantly smells like summer vacation — warm, beachy, and nostalgic without being overpowering. I’ll definitely be repurchasing before my upcoming vacation because it makes such a noticeable difference in how my skin looks and feels after sun exposure.
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Reviewed in the United States on March 3, 2026
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Luna
Lexington, US
★★★★★ 4
Better than expected!
I was pleasantly suprised by this lotion. I bought it to help maintain my self tanning lotion, and also for days after being in the sun. The lotion is not too thick and not sticky. The scent is tropical and nice, bit it’s not too strong. I will buy this lotion again.
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Reviewed in the United States on June 22, 2025
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Amazon Customer
Battle Creek, US
★★★★★ 5
Hydrating
A nice lotion, smell is good, not great, but hydrates well.
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Reviewed in the United States on May 23, 2026

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