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Description
TLR4 Recombinant Mouse mAb,PBS Only (SDT-3305)Product Specification Host Mouse Antigen TLR4 Synonyms Toll like receptor 4; CD284; Lps; Tlr4 Location Endosome, Cell membrane Accession Q9QUK6 Clone Number SDT 3305 Antibody Type Mouse mAb Isotype IgG2b,k Application IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Pig Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt reconstitution, 4
Product Specification
| Host | Mouse |
| Antigen | TLR4 |
| Synonyms | Toll-like receptor 4; CD284; Lps; Tlr4 |
| Location | Endosome, Cell membrane |
| Accession | Q9QUK6 |
| Clone Number | SDT-3305 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Pig |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Hu |
Background
Toll-like receptor 4 (TLR4) is a type I transmembrane pattern-recognition receptor expressed predominantly on macrophages, dendritic cells, and epithelial barriers; upon recognition of lipopolysaccharide from Gram-negative bacteria in complex with MD-2 and CD14, it homodimerizes and initiates a MyD88- and TRIF-dependent signaling cascade that activates NF-κB, MAPKs, and IRF3, driving the transcription of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), type I interferons, and co-stimulatory molecules essential for innate immunity and the subsequent shaping of adaptive responses, while excessive or dysregulated TLR4 activation contributes to septic shock, chronic inflammatory disorders such as atherosclerosis and metabolic syndrome, and ischemia–reperfusion injury, making it a therapeutic target for antagonists like lipid A analogs and monoclonal antibodies.
Shipping Notes
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Exchange/Return Notes
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