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Description
IL-21 R His Tag Protein, HumanProduct Specification Species Human Synonyms IL21R, CD360, NILR Accession Q9HBE5 1 Amino Acid Sequence Cys20 Pro236 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 35 50kDa (Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | IL21R, CD360, NILR |
| Accession | Q9HBE5-1 |
| Amino Acid Sequence | Cys20-Pro236 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 35-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC. Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):868-77. |
Background
IL-21 receptor (IL-21R/CD360/NILR) belongs to the type I cytokine receptor family, subfamily 4. It is a single-pass transmembrane protein composed of two fibronectin type-III domains, a WSXWS folding motif and a Box1 JAK-binding motif, and together with the common γ-chain it forms the high-affinity IL-21 receptor complex. Selectively enriched in thymus and spleen, IL-21R is broadly expressed on T, B and NK cells and, via the JAK-STAT pathway, transduces IL-21 signals that drive proliferation, differentiation and memory formation, thereby bridging innate and adaptive immunity. Clinically, hyper-activation of the IL-21/IL-21R axis promotes autoantibody production and is implicated in multiple autoimmune diseases, making this pathway a key biomarker and therapeutic target for autoantibody-mediated disorders.
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