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Description
BAFF&APRIL Heterotrimer His Tag Protein, HumanProduct Specification Species Human Synonyms BAFF&APRIL Accession Q9Y275O75888 Amino Acid Sequence Glu140 Leu285&Gln111 Leu250 with His Tag at the N Terminus Expression System HEK293 Molecular Weight 45 65kDa (Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Human |
| Synonyms | BAFF&APRIL |
| Accession | Q9Y275、O75888 |
| Amino Acid Sequence | Glu140-Leu285&Gln111-Leu250 with His Tag at the N-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 45-65kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Wiggins CD, Sangés Ametllé M, Wu C, Boswell KL, Watkins TA, Koup RA, Lauffenburger DA. Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell system. bioRxiv [Preprint]. 2025 Oct 2:2025.09.30.679651. |
Background
BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand) are members of the tumor necrosis factor (TNF) superfamily. They typically exist as homotrimers but can also form heterotrimers. Secreted by activated myeloid cells, they exert immunomodulatory effects by regulating B-cell differentiation, proliferation, survival, and effector functions. Clinically, dysregulated expression of the BAFF/APRIL system is closely associated with autoimmune diseases, particularly with significantly elevated levels observed in patients with systemic lupus erythematosus (SLE). The detection of circulating heterotrimers in the serum of patients with systemic immune rheumatic diseases suggests that these heterotrimers may represent a novel therapeutic target for rheumatic and autoimmune disorders.
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