SKU: 77439014036

Alexa Fluor® 488 Armenian hamster Anti-Mouse TCR γ/δ Antibody (S-R525)

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Description

Alexa Fluor® 488 Armenian hamster Anti-Mouse TCR γ/δ Antibody (S-R525)Product Specification Host Armenian hamster Antigen TCR Location Cell membrane Accession 110066 110067 Clone Number S R525 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2

Product Specification


Host Armenian hamster
Antigen TCR γ/δ
Location Cell membrane
Accession 110066、 110067
Clone Number S-R525
Antibody Type Recombinant mAb
Isotype IgG
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse splenocytes
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Ms

Background

TCR γ protein is a key component of the γδ T cell receptor (TCR), which is a heterodimer comprising TCRγ and TCRδ chains. Unlike the αβ TCR, which primarily recognizes peptide antigens presented by MHC molecules, the γδ TCR can identify a diverse range of antigens in an MHC-independent manner. This includes small phosphorylated non-peptide antigens, such as those produced by cellular pathogens and cancers. The γδ TCR is associated with three CD3 dimeric subunits—CD3εγ, CD3εδ, and CD3ζζ—forming an octameric γδ TCR–CD3 complex. This complex plays a crucial role in the immune response by triggering the phosphorylation of ITAMs within the cytoplasmic tails of CD3 subunits upon antigen engagement, initiating downstream signaling events. The γδ TCR–CD3 complex is an attractive target for cancer immunotherapy due to its unique properties and effector functions. TCR δ protein is a component of the γδ T cell receptor (TCR), forming a heterodimer with TCR γ chain. This γδ TCR is expressed on γδ T cells, which are a unique subset of T cells with both adaptive and innate immune characteristics. Unlike αβ TCRs that primarily recognize peptide antigens presented by MHC molecules, γδ TCRs can recognize a diverse range of antigens in an MHC-independent manner. TCR δ, along with TCR γ, undergoes somatic recombination of V, D, and J gene segments to generate diversity. The γδ TCR-CD3 complex, which includes TCR γ, TCR δ, and CD3 subunits, plays a crucial role in antigen recognition and T cell activation. Upon antigen binding, the complex triggers the phosphorylation of ITAMs in the CD3 subunits, initiating downstream signaling pathways that lead to T cell proliferation, differentiation, and effector functions. This makes the γδ TCR-CD3 complex an attractive target for cancer immunotherapy, as it can provide broad protective immune responses against various infections and tumors.

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SKU: 77439014036

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