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Description
SEZ6 Recombinant Rabbit mAb,PBS Only(SDT-2097-7)Product Specification Host Rabbit Antigen SEZ6 Synonyms Seizure protein 6 homolog; SEZ 6; hSEZ 6 Immunogen Recombinant Protein Location Cell membrane Accession Q53EL9 Clone Number SDT 2097 7 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample H69 Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | SEZ6 |
| Synonyms | Seizure protein 6 homolog; SEZ-6; hSEZ-6 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q53EL9 |
| Clone Number | SDT-2097-7 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | H69 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:250 | Hu |
Background
SEZ6 (Seizure-related gene 6) is a type I transmembrane glycoprotein (~110 kDa) composed of five short consensus repeat (SCR) domains, three CUB domains, a single transmembrane segment and a short cytoplasmic tail that is predominantly expressed in the central nervous system, where it acts as a critical trafficking chaperone for kainate receptor subunits GluK2/3, ensuring their proper N-glycosylation (including the HNK-1 epitope), post-ER export and surface localization to regulate synaptic connectivity, long-term potentiation and dendritic arbor balance, and is sequentially cleaved by BACE1 and γ-secretase to release a soluble ectodomain whose CSF level serves as a direct pharmacodynamic read-out of BACE1 inhibition, while in neuroendocrine neoplasms its selective over-expression is exploited as an ADC target for therapies against small-cell lung cancer and related tumors.
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