SKU: 77152377152

IL-23 R Fc Chimera Protein, Human

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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 77152377152

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4.2 ★★★★★
Based on 22 reviews
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Brian Delacruz
Waukegan, US
★★★★★ 5
Great
Great
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Reviewed in the United States on April 17, 2026
D
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Dawn S.
New York, US
★★★★★ 5
OEM quality and perfect fit with no leaks
Size: 1 Count
This is the real deal for anyone wanting to stick with OEM parts for their Chrysler or Dodge vehicle. The filter arrived sealed and well-packaged, and installation was quick with no surprises. This fits my 2016 Chrysler 300 sedan. It fits perfectly and performs just like the one from the dealership but without the inflated price. There were no leaks, and oil pressure stayed consistent post-change. If you're doing your own oil changes, it’s worth sticking with a filter that’s built specifically for your engine - this one does the job right. Pros: True OEM fit and function Well-sealed and clean install Performs reliably Tip: Pre-fill the filter with oil before installation to reduce dry start wear and improve circulation right away.
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Reviewed in the United States on June 26, 2025
S
Verified Purchase
Scruffy
Dallas, US
★★★★★ 5
Mopar Quality
Size: 1 Count
I regularly buy Mopar filters for my vehicles and have never had a problem with them. These are great filters at a good price and of course it is very convenient buying on Amazon.
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Reviewed in the United States on October 20, 2025
H
Verified Purchase
Hal Weaver
Dallas, US
★★★★★ 5
The Genuine Deal
Size: 1 Count
OEM filter. Works exactly as it should. My application is for a 2016 Jeep Cherokee, 3.2L.
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Reviewed in the United States on December 31, 2025
R
Verified Purchase
RS - Las Vegas, NV
Belleville, US
★★★★★ 5
Great Fit, No Problems.
Size: 1 Count
Great Factory part that's easy to install and performs as one would expect. Have purchased this part many times for my wife's Jeep and never had any problems.
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Reviewed in the United States on March 30, 2026

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