SKU: 69421425830

FGF-6 Protein, Human

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Description

FGF-6 Protein, HumanProduct Specification Species Human Synonyms Fibroblast growth factor 6, FGF 6, Heparin secretory transforming protein 2 (HST 2; HSTF 2), Heparin binding growth factor 6 (HBGF 6) Accession P10767 Amino Acid Sequence Gly41 Ile208 Expression System E. coli Molecular Weight 14 15 kDa (Reducing) Purity >95% by SDS PAGE, >90% by HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4

Product Specification


Species Human
Synonyms Fibroblast growth factor 6, FGF-6, Heparin secretory-transforming protein 2 (HST-2; HSTF-2), Heparin-binding growth factor 6 (HBGF-6)
Accession P10767
Amino Acid Sequence

Gly41-Ile208
Expression System E.coli
Molecular Weight

14-15 kDa (Reducing)
Purity >95% by SDS-PAGE, >90% by HPLC.
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Reference

Genes & Dev. 1997;11(16):2040-2051.
Nat Commun. 2020;11(1):1421.

Background

Fibroblast growth factor 6 (FGF-6), also designated as HST2 or HBGF-6, is a secreted peptide growth factor belonging to the paracrine FGF subfamily. The FGF6 gene, located on human chromosome 12p13, encodes an 18.9 kDa protein that exhibits the highest expression in skeletal muscle and myogenic progenitor cells throughout embryonic development and adulthood. FGF-6 binds preferentially to fibroblast growth factor receptor 4 (FGFR4) with heparan sulfate proteoglycan co-receptor dependency, triggering downstream signaling through the MAPK/ERK1/2 and PI3K/AKT pathways.Functionally, FGF-6 operates as a dose-dependent regulator of myogenesis, promoting satellite cell proliferation at high concentrations and initiating myogenic differentiation via calcineurin-dependent pathways at lower concentrations. Beyond muscle physiology, FGF-6 exhibits pleiotropic functions in bone remodeling, iron homeostasis, thermogenesis, and oncogenesis, harboring both regenerative and tumorigenic activities.
Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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SKU: 69421425830

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4.6 ★★★★★
Based on 14 reviews
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Product Reviews
C
Verified Purchase
Carmen Langton-Anson
Birmingham, US
★★★★★ 5
Good toy for tough chewer.
Color: Hammer, Size: 7 Inch
My dog loved this toy. I would purchase again. Was a pretty tough toy, lasted longer than most.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 29, 2026
N
Verified Purchase
Nathan R
Lake Worth, US
★★★★★ 5
Durable
Color: Hammer, Size: 7 Inch
Even my monster hasn't been able to chew through these in a few months, and he has destroyed one of the black Kongs in the same time frame.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 24, 2026
D
Verified Purchase
Darling
Omaha, US
★★★★★ 5
Tough to destroy for aggressive chewers
Color: Wrench, Size: 8 Inch
My doggie chewed out stairscase, the sofa, my shoes, and would destroy anything labeled pet “tough” toys. This stopped her from destroying!! Soo cool and cleans her teeth too. I got this one as gift for other retriever fams! Super cool. Doesn’t smell bad and its lightweight but durable like crazy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 30, 2026
A
Verified Purchase
Amazon Customer
Phoenix, US
★★★★★ 5
Great Chew Toy
Color: Wrench, Size: 8 Inch
An excellent chew toy for a very hearty chewer.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 6, 2026
C
Verified Purchase
Concerned Citizen
Charlottesville, US
★★★★★ 4
Great Toy for Chewers!
Color: Hammer, Size: 7 Inch
This is one of my dog’s favorite toys! He will chew on it for hours. It is durable and takes him a while to make it indistinguishable as a hammer. No smell to it. The rubber bits do come off so I have to check it and make sure he doesn’t eat them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 10, 2025

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