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Description
GSPT1 Recombinant Rabbit mAb (S-1914-49)Product Specification Host Rabbit Antigen GSPT1 Synonyms Eukaryotic peptide chain release factor GTP binding subunit ERF3A; Eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog Immunogen Synthetic Peptide Location Cytoplasm Accession P15170 Clone Number S 1914 49 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, HepG2, 293T, NIH 3T3, Neuro 2a, PC
Product Specification
| Host | Rabbit |
| Antigen | GSPT1 |
| Synonyms | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P15170 |
| Clone Number | S-1914-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HepG2, 293T, NIH/3T3, Neuro-2a, PC-12, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:3000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
GSPT1, also known as eukaryotic release factor 3a (eRF3a), is a GTP-binding protein that plays a crucial role in both translation termination and cell cycle regulation. It functions by binding with eRF1 to dissociate proteins from the ribosome after translation, thus regulating cell cycle progression from the G1 to S phase. GSPT1 is overexpressed in various cancers, including gastric, colorectal, lung, and breast cancers, making it a promising target for cancer therapy. Additionally, GSPT1 is involved in cytoskeleton organization and apoptosis. Its degradation through molecular glue degraders, such as CC-885, has been shown to exert strong antitumor activity.
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