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Description
SEC23B Recombinant Rabbit mAb (S-1935-28)Product Specification Host Rabbit Antigen SEC23B Synonyms Protein transport protein Sec23B; hSec23B; SEC23 related protein B Immunogen Synthetic Peptide Location Cytoplasm, Endoplasmic reticulum Accession Q15437 Clone Number S 1935 28 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample K562, Raji, MDA MB 231, MCF7, SW620, RAW264. 7, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | SEC23B |
| Synonyms | Protein transport protein Sec23B; hSec23B; SEC23-related protein B |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Endoplasmic reticulum |
| Accession | Q15437 |
| Clone Number | S-1935-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, Raji, MDA-MB-231, MCF7, SW620, RAW264.7, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
SEC23B, also known as Sec23 homolog B, is a crucial component of the coat protein complex II (COPII), which is involved in the transport of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. This gene plays a significant role in cellular processes such as autophagy regulation and cell migration. Recent studies have shown that SEC23B can induce autophagy in breast cancer cells by inhibiting the ERK/mTOR signaling pathway, thereby promoting cancer cell metastasis. Additionally, SEC23B has been implicated in various cancers, including thyroid cancer, hepatocellular carcinoma, and prostate cancer, suggesting its potential as a therapeutic target.
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